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Medical Hyaluronic Acid Cold Gel
Ingredient: 20mg/ml hyaluronic acid
Specification: 1ml, 2ml, 3ml, 5ml, 10ml, 20ml, 50ml
Package: Syringe
Recommended use: 1-3 pcs, 12 months apart
Application Area:
Apple cheek muscle, neck lines, forehead lines, eyes, lips, back of hand, nasolabial groove, mouth pouch, marionette lines etc
Product Introduction：
Cross-linking involves chemically bonding HA molecules together using agents such as BDDE (1,4-Butanediol diglycidyl ether), which creates a three-dimensional network. This network resists enzymatic degradation, giving the filler a longer-lasting, more stable, and more sculptable consistency. Unlike non-cross-linked HA, which may dissolve in a matter of days or weeks, cross-linked HA fillers can last from 6 to 18 months, depending on the formulation and injection site.
This breakthrough has led to the development of specialized fillers tailored for different facial areas—such as deep wrinkle correction, lip enhancement, chin augmentation, and tear trough treatment. Cross-linked HA fillers offer clinicians superior precision and patients natural, smooth results with minimized risk of migration or overfilling.
Product Display：
Product Details:
Type | Fine |
Ingredient | |
Specification | 1ml, 2ml, 3ml, 5ml, 10ml, 20ml, 50ml |
Cross Link | BDDE chemical cross link |
Texture | Gel |
Elasticity | 50 Pa-200 Pa |
Viscosity | 20 Pa-40Pa |
Mean particle size | 150μm-350μm |
Effective content | 20mg/mL |
Cross linker residue | No,or≤0.5ug/g |
Protein residue | ≤20μg/g |
Endotoxin content | <0.5EU/mL |
Swelling degree | 40-60 |
Extruding force | 15N-22N |
Application area | Apple cheek muscle, neck lines, forehead lines, eyes, lips, back of hand, nasolabial groove, mouth pouch, marionette lines etc |
Package | Syringe |
Stoarge | Room temperature (1-25ºC), cool and dry place |
Recommended | 1-3 pcs (vary with each individual |
Recommended interval | 12 month |
Product Package:
Clinical Benefits and Safety
Multiple clinical studies have demonstrated that cross-linked HA provides superior viscoelastic properties, making it ideal for deep tissue support and volume restoration. The gel’s firmness (G prime) and cohesiveness can be adjusted during the manufacturing process to meet different clinical needs. This has led to the rise of customized filler lines for specific facial zones.
Cross-linked HA fillers are also biocompatible, non-animal derived, and generally well tolerated by patients. Adverse events are rare and typically limited to mild bruising, swelling, or tenderness at the injection site. Reversible effects (via hyaluronidase) further boost confidence among both doctors and patients.
Customer Feedback:
Applications in Aesthetic Treatments
Nasolabial folds: Deep lines around the mouth are softened with high-density cross-linked HA fillers.
Lip augmentation: Medium-cohesiveness HA offers natural volume and shape with minimal lump formation.
Chin and jawline sculpting: High-viscosity gels enhance structure and projection.
Tear trough correction: Specialized low-density HA smooths the under-eye area for a refreshed look.
Development Process:
Innovation and the Future
Next-generation fillers are pushing boundaries with smart HA technology—including bio-stimulatory ingredients, slow-release formulations, and regenerative components like peptides and PCL microspheres. The integration of cross-linked HA with growth factors or stem cell-derived exosomes is under exploration, promising even greater skin rejuvenation outcomes.
Manufacturers are also investing in AI-powered injection guidance systems, microcannula techniques, and personalized treatment plans to ensure safety and precision.
